DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

ATR 激酶是应对 DNA 复制应激（RS）的关键调节因子，在癌细胞中，许多遗传突变会导致 RS 水平升高，而 ATR 在维持复制叉的稳定性和促进细胞存活方面发挥着重要作用。抑制 ATR 可使癌细胞因复制叉崩溃和有丝分裂灾难而死亡，因此 ATR 成为癌症治疗的潜在靶点。目前，基于 ATR 抑制剂（ATRi）的临床试验正在开展，但尚未建立有效的治疗方案。

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell ...

DNA damage can result in the genetic sequence being misread and copied during cell division -- known as DNA replication -- and this introduces permanent mutations that can contribute to the ...

Announcing a new article publication for Zoonoses journal. Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin ...

In a study that appears in the journal Cell, scientists from San Francisco-based Gladstone Institutes—including co-first author Megan Ostrowski (left) and senior author Vijay Ramani, ...

In the double helix structure of DNA, thymine forms a base pair with adenine through two hydrogen bonds. This specific pairing is known as complementary base pairing and is essential for the stability ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...

The reliability of the DNA replication process depends on genome stability, which is maintained by DNA repair mechanisms that correct any mistakes that occur during DNA replication. Failures in ...

Old viral DNA, once thought to be gone forever, is reactivated in mammalian embryos, with each species showing unique ...