Figure 2: Retinoblastoma protein and cell-cycle progression. Recent experiments have implicated one specific E2F target, CDC6, as a potentially important marker for quiescence. CDC6 has a crucial ...

"This work is an effort to understand how the activity of E2F is coordinated with the cell cycle. We show that regulation of E2F involves an interaction with Rb in G1, whereas in S phase, E2F forms a ...

Maintaining treatment with CDK4/6 inhibitors significantly suppresses the growth of breast cancer cells, even after drug resistance has developed, according to new research.