The disorder is marked by reticulocytopenia, which is a decrease in reticulocytes (immature red blood cells), and a notable absence of erythroid precursors in the bone marrow. Recent research has ...

Recent research has shed light on the complex regulation of erythroid cells, revealing their multifaceted roles not only in oxygen transport but also in immune responses and disease contexts.

Higher EPO and HIF lead to the secretion of ERFE from erythroid precursor cells, which attenuates the BMP6 signaling cascade via GDF15/TWSG1. In the absence of BMP6, TMPRSS6 binds to ALK2 ...