Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

A new study in Engineering explores the role of astrocytic G protein-coupled receptors in drug addiction. It shows that these ...

Studies Kaposi’s sarcoma herpesvirus (KSHV) G protein-coupled receptor (GPCR) contribution to metabolic regulation, trafficking and signaling, using tissue culture models and molecular biology ...

Image Credit: Volha_R/Shutterstock.com Proteins are nature’s functional building blocks and perform diverse tasks such as signaling, binding, and catalysis. G protein-coupled receptors (GPCRs ...

including agonists (which activate GPCR signaling), antagonists (which inhibit GPCR signaling), and allosteric modulators (which fine-tune GPCR activation by endogenous ligands). This approach ...

Key GPCR family receptors that are related to diseases. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or ...

This newly published analysis in Genes & Diseases sheds light on the crucial role of mechanosensitive adhesion G protein-coupled receptors (aGPCRs) in regulating biological processes and their ...

Sánchez MF, Tampé R. (2022) Ligand-independent signaling by receptor condensates: a new paradigm. Trends in Biochem Sci 48: 156–171. Sánchez MF, Els-Heindl S, Beck-Sickinger A-G, Wieneke R, Tampé R.