With this knowledge, scientists are seeking to better understand the role of GPCRs in islet biology and hormone secretion, and how signaling in the cell through these receptors is disrupted in ...

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

The GPCR and plant-like transporter work together ... who leads the Structural Biology of Signaling and Cancer lab at the ...

including agonists (which activate GPCR signaling), antagonists (which inhibit GPCR signaling), and allosteric modulators (which fine-tune GPCR activation by endogenous ligands). This approach ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs).

The German Research Foundation (DFG)-funded Collaborative Research Centre 1423, “Structural Dynamics of GPCR Activation and Signaling”, is currently working intensively in this area.

More information: Kun-Yang Lin et al, Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling, Science Advances (2024). DOI: 10.1126/sciadv.adl4694 Provided ...

This newly published analysis in Genes & Diseases sheds light on the crucial role of mechanosensitive adhesion G protein-coupled receptors (aGPCRs) in regulating biological processes and their ...

Studies Kaposi’s sarcoma herpesvirus (KSHV) G protein-coupled receptor (GPCR) contribution to metabolic regulation, trafficking and signaling, using tissue culture models and molecular biology ...

(2022) Ligand-independent signaling by receptor condensates: a new paradigm. Trends in Biochem Sci 48: 156–171. Sánchez MF, Els-Heindl S, Beck-Sickinger A-G, Wieneke R, Tampé R. (2021) Photo-induced ...