在抗击肿瘤的努力中，科学家们不断探索新的免疫治疗方法。最近，来自华东师范大学生命科学学院的江文正教授及其团队成功发现了一种新型免疫检查点——GPR132，预计将为CAR-NK细胞疗法的应用提供新的契机。江文正出生于安徽桐城，现任生命科学学院副院长，并担任生命医学系教授及博士生导师，长期致力于研究G蛋白偶联受体（GPCR）对免疫细胞（如自然杀伤细胞NK、树突状细胞DC和T细胞）的调控。

Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

A new study in Engineering explores the role of astrocytic G protein-coupled receptors in drug addiction. It shows that these ...

Studies Kaposi’s sarcoma herpesvirus (KSHV) G protein-coupled receptor (GPCR) contribution to metabolic regulation, trafficking and signaling, using tissue culture models and molecular biology ...

Image Credit: Volha_R/Shutterstock.com Proteins are nature’s functional building blocks and perform diverse tasks such as signaling, binding, and catalysis. G protein-coupled receptors (GPCRs ...

including agonists (which activate GPCR signaling), antagonists (which inhibit GPCR signaling), and allosteric modulators (which fine-tune GPCR activation by endogenous ligands). This approach ...

Key GPCR family receptors that are related to diseases. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or ...

Sánchez MF, Tampé R. (2022) Ligand-independent signaling by receptor condensates: a new paradigm. Trends in Biochem Sci 48: 156–171. Sánchez MF, Els-Heindl S, Beck-Sickinger A-G, Wieneke R, Tampé R.

This newly published analysis in Genes & Diseases sheds light on the crucial role of mechanosensitive adhesion G protein-coupled receptors (aGPCRs) in regulating biological processes and their ...