In NF1, many of these medications work by blocking a specific cell signaling pathway called Ras/MAPK that is hyperactive in cells that have lost NF1 function due to gene mutation. When this signaling ...
The medication acts as an inhibitor of the RAS/MAPK cellular signaling pathway that is hyperactive in people with NF1. The RAS/MAPK pathway achieves its signaling through a complex form of cell ...
News Medical on MSN6d
New treatment identified for peripheral nerve sheath tumorsA multicenter collaboration led by the Bellvitge Biomedical Research Institute (IDIBELL) - Institut Català d'Oncologia (ICO) ...
Affected children are born with café-au-lait spots and sometimes Lisch nodules. During adolescence and young adulthood, more ...
A multicenter collaboration has identified a potential new treatment for an aggressive sarcoma arising in the nerves. The ...
The researchers were able to precisely measure a cell's response to damaged DNA at the single-cell level and observed a new pathway to the activation of NF-κB. They found that after specific ...
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