Figure 1: The Sonic hedgehog (Shh) signaling cascade is important in ... “The search is really on for additional ways to target the pathway.” Several groups have made progress in finding ...

“These damages cause the cilia to stop working properly,” explains Mathias De Decker, first author of the study. “We saw that an important signaling pathway – the sonic hedgehog (Shh) signaling ...

This interaction is vital for proper guidance of developing axons. During embryonic development, Shh acts as a guidance signal, attracting axons. The team led by Charron, who also holds the Canada ...