gut.bmj16h
Maintenance of normal intestinal mucosa: function, structure, and adaptation.
Histopathology Unit, Imperial Cancer Research Fund, Royal College of Surgeons, London. Diet is of fundamental importance in the healthy functioning of alimentary epithelium, or during the disease ...
gut.bmj2d
UK key performance indicators and quality assurance standards for colonoscopy
Colonoscopy should be delivered by endoscopists performing high quality procedures. The British Society of Gastroenterology, the UK Joint Advisory Group on GI Endoscopy, and the Association of ...
gut.bmj2d
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...
gut.bmj22h
Specific adaptation of gastric emptying to diets with differing protein content in the rat: is endogenous cholecystokinin implicated?
Background—Recent studies indicate that gastric emptying may be influenced by patterns of previous nutrient intake. Endogenous cholecystokinin (CCK), whose synthesis and release can be affected by ...
gut.bmj2d
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined interactions between ...
gut.bmj2d
Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer
1 Department of Radiology, Georges-Francois Leclerc Cancer Cente, Dijon, France 2 Department of Radiology, Le Bocage University Hospital, Dijon, France 3 Department of Endocrinology, Diabetology and ...
gut.bmj2d
Apoptosis: a mechanism of acute and chronic liver injury
Correspondence to: Dr G J Gores Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA; gores.gregorymayo.edu ...
gut.bmj9d
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer
Correspondence to Professor Xian-Jun Yu, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; yuxianjun88{at}hotmail.com Design We combined molecular ...
gut.bmj5d
Optimal age to discontinue long-term surveillance of intraductal papillary mucinous neoplasms: comparative cost-effectiveness of surveillance by age
3 Graduate School of Public Health, St Luke’s International University, Tokyo, Japan Objective Current guidelines recommend long-term image-based surveillance for patients with low-risk intraductal ...
gut.bmj2d
Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis
Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk of infection. This investigation evaluated prevalence and characteristics ...
gut.bmj2d
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas
7 Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China Objective Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, ...
gut.bmj8d
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...