Elevated PKA competitively inhibits PDE9A degradation, with PDE9A accumulation further disrupting the balance between cGMP-cAMP signalling pathways. PDE9A inhibition via Bay 73-6691 or CHIP ...

These processes are genetically controlled and depend both on the history of cells (lineage) and on the activities of signalling pathways, which coordinate the cell interactions leading to ...

Credit: Dr. Tetsuya Muramoto The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and ...

A study published in the Journal of Neuroscience sheds new light on how brain cells relay critical information from their ...

This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following ...

We hypothesized that the mechanical stretch caused by UPLS can be sensed by PECAM-1 in the lungs, leading to VILI via the Src/STAT3 and pyroptosis pathway. Results: UPLS activated PECAM-1, Src/STAT3 ...

Scientists have uncovered a crucial pathway that links brain cell activity to the activation of genes responsible for ...