Early in the development of chloramphenicol toxicity, vacuoles appear in the erythroid and myeloid precursors of the bone marrow. 1–4 The relation of these early, reversible lesions to later ...

Castruccio Castracani and his team developed a lentiviral vector that activated the human ALAS2 gene in erythroid cells, or cells that serve as precursors to normal red blood cells. They found ...