G protein-coupled receptors (GPCRs) remain a focal point of research due to their critical roles in cell signaling and their prominence as drug targets. However, directly linking drug efficacy to the ...

After hours: March 10 at 7:29:36 PM EDT Loading Chart for GPCR ...

This study makes the fundamental discovery of the first natural animal rhodopsin that uses a chloride ion instead of an amino acid side chain as a counterion. Using a combination of biochemical and ...

在抗击肿瘤的努力中，科学家们不断探索新的免疫治疗方法。最近，来自华东师范大学生命科学学院的江文正教授及其团队成功发现了一种新型免疫检查点——GPR132，预计将为CAR-NK细胞疗法的应用提供新的契机。江文正出生于安徽桐城，现任生命科学学院副院长，并担任生命医学系教授及博士生导师，长期致力于研究G蛋白偶联受体（GPCR）对免疫细胞（如自然杀伤细胞NK、树突状细胞DC和T细胞）的调控。

Alphabet subsidiary and precision health company Verily recently announced a breakthrough in its AI drug discovery GPCR research collaboration with Sosei Heptares. A mere six months ago Verily ...

NK细胞是人体免疫系统的核心成员，能够直接识别并杀伤癌细胞，尤其在对抗MHC分子缺陷的肿瘤细胞时展现出独特优势。然而，肿瘤微环境（TME）中的低氧条件会代谢产生大量乳酸，严重抑制NK细胞的活性，导致其抗癌能力下降。如何逆转这一抑制效应，成为免疫治疗领 ...