Genetic polymorphisms have been described in the case of several CYP isoenzymes ... mediated interactions Ticlopidine ↑ PPI effect Inhibition of omeprazole 5'-hydroxylation, decreased ...

For example, Ubrelvy can interact with certain drugs called strong CYP3A4 inhibitors, such as clarithromycin. Ubrelvy is taken by adults to treat certain kinds of migraine episodes. An interaction ...

Eplerenone has an elimination half-life of 4 6 hours. Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir. About 50% is bound by plasma protein.

those who were taking other potential CYP3A4, OATP1B1 or OATP1B3 inhibitors or substrates 180 days prior to the index date (medications such as protease inhibitors, statins, antifungals and calcium ...

Pfizer Inc. today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of BRAFTOVI® (encorafenib) in combination with cetuximab ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

Recent research has focused on identifying and developing inhibitors of CYP121A1, utilizing various innovative strategies to enhance drug discovery and efficacy against TB. Recent studies have ...

ETR has the potential for drug-drug interaction (DDI) with CYP2C8, CYP2C9, and CYP3A4 when coadministered with inhibitors or inducers of these enzymes. This open-label Phase 1 study evaluated the ...

Rigel Pharmaceuticals, Inc.  today announced the first patient has been enrolled in a Phase 1 study evaluating the safety and tolerability of escalating doses of fostamatinib, the company's oral ...

Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune ...

Avoid co-administration of XOLREMDI and strong CYP3A4 inducers. Reduce XOLREMDI daily dosage when administered with strong CYP3A4 inhibitors. Monitor more frequently for adverse reactions associated ...