Besides their role in thrombosis and hemostasis, platelets can also stimulate fibrosis and tumor development by secreting profibrogenic factors and regulating the innate immune response, e.g., by ...

The result of these concurrent steps is the formation of a mural platelet thrombus that forms a scaffold to initiate coagulation, hemostasis, and healing of the injured vessel (Figure 1). To prevent ...

Polyphosphate (polyP) exists in all life forms; however, its biological functions in metazoans are understudied. Here, we explored Drosophila as the first genetic model to explore polyP biology in ...

This first stage of blood clotting is known as primary hemostasis. Once the platelets form a temporary plug, blood-clotting factor II (prothrombin) changes to its activated version, factor IIa ...

Thrombocytopenia, which is a low platelet count, can be caused by problems in the bone marrow or the immune system. The bone marrow may not make enough platelets, or the immune system may destroy ...

Request permissions for this article. Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary (E. Buzas). HUN-RE-SU Translational Extracellular Vesicle Research Group, ...

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