Scientists gain valuable insights into cellular diversity and functions, disease mechanisms, developmental processes, and drug responses by examining the transcriptome of tissues using single-cell RNA ...

Sickle cell disease (SCD) with concurrent systemic lupus erythematosus (SLE) is an uncommon but significant association requiring heightened clinical awareness, according to results from a ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

For analysis of γδ T cells in PBMCs, after isolation and stimulation, the cells were gated on single cells, time, NEAR-IR negative events and CD3, Vδ1 or Vδ2 positive events. For analysis of target ...

Recent studies of complex trait diseases have indicated that many disease susceptibility variants regulate the expression levels of a number of genes that function in a cell-specific manner ...

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Updated specific recommendations are also provided for cutaneous, neuropsychiatric and haematological disease, SLE-associated antiphospholipid syndrome, kidney protection, as well as preventative ...

Jan. 21, 2025 — Researchers identified a key protein as a potential therapeutic target for stopping the body's immune system from mistakenly attacking itself, offering new hope for treating ...

Genetic alterations may help mosquitoes adjust to climate change, shifting the distribution of mosquito-borne disease in a warming planet.