However, most therapeutic agents, especially chemotherapy, have no intrinsic affinity for tumor vessels, which can cause severe drug resistance and systemic side effects. An increasing number of ...

Cancer Cell 6: 553-563 Tumor vessels have structural and functional abnormalities, which impair tissue oxygenation and drug delivery, and may induce resistance to therapy. Glioblastoma multiforme ...

T argeting and customizing blood vessels in tumors to increase T cell infiltration and maintain their function may represent ...

Brain tumors often rely on blood vessel cells, also known as vascular endothelial cells, to fuel their growth. These tumor blood vessels not only supply oxygen and nutrients, but also produce ...

Judah Folkman's most significant findings in a career rife with discoveries was that cancerous tumors appear to trigger the growth of new blood vessels, which the tumors need to thrive.

contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis. The findings could change how these diseases are treated. Researchers at Oregon Health & Science ...

The team of researchers discovered that endocan, which is produced by endothelial cells lining blood vessels in the tumor, activates PDGFRA, a receptor on glioblastoma cells that drives tumor ...

Pancreatic tumors are notoriously hard to treat. One of the reasons is they are filled with so much pressure that blood vessels collapse and cancer-fighting drugs can’t get in. But now researchers ...