In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Scientists are tackling society's growing obesity problem from all kinds of angles – and new research picks out a particular ...

Researchers from Kumamoto University have identified a liver-derived protein, serine protease inhibitor A1 (SerpinA1), as a key regulator in combating obesity and enhancing glucose metabolism.

SerpinA1 interacts with the cell surface molecule EphB2 to trigger pathways that enhance UCP1 expression and mitochondrial activity in adipocytes. This finding reveals a novel signaling mechanism ...