The absence of p53 significantly accelerates the progression from Barrett's esophagus to cancer. So, the researchers discovered that cells losing both CDKN2A and p53 became weaker and less capable ...

In the p53 pathway, signals such as DNA damage induce the ARF (also known as p14 in humans and p19 in mice) product of the CDKN2A locus. ARF increases p53 levels by sequestering MDM2, which ...

Loss of p53 strongly drives the progression of disease from Barrett’s to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...