Elevated PKA competitively inhibits PDE9A degradation, with PDE9A accumulation further disrupting the balance between cGMP-cAMP signalling pathways. PDE9A inhibition via Bay 73-6691 or CHIP ...

These processes are genetically controlled and depend both on the history of cells (lineage) and on the activities of signalling pathways, which coordinate the cell interactions leading to ...

Credit: Dr. Tetsuya Muramoto The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and ...

This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following ...

A study published in the Journal of Neuroscience sheds new light on how brain cells relay critical information from their ...

We hypothesized that the mechanical stretch caused by UPLS can be sensed by PECAM-1 in the lungs, leading to VILI via the Src/STAT3 and pyroptosis pathway. Results: UPLS activated PECAM-1, Src/STAT3 ...

Finally, we observed differences between CS1 and CS2 in various metabolic pathways, biological processes, and signaling pathways, such as fatty acid metabolism, hypoxia levels, and the PI3K-AKT ...