尽管如此，本研究为 65 岁以上老年人接种三种基于蛋白的含 XBB 疫苗后的中和抗体反应提供了重要证据，为优化老年人群疫苗接种策略、增强对新兴 SARS-CoV-2 变体的中和免疫力提供了关键信息。未来需进一步研究不同给药途径疫苗诱导的免疫特征、年龄对加强免疫后免疫力持久性的影响以及疫苗对新变体的效力等问题，以更好地应对新冠疫情，保障老年人群健康。

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