An isogenic cell line was created to model cancer patients with the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene and tested for its ...

A study presented at the AACR meeting showed that Resolution's ctDx-Lung assay reported more oncogenic fusions than Guardant360 in NSCLC patients. Pfizer's Xalkori yielded significantly longer ...

When this fusion happens, a patient is said to be ALK-positive. The most common gene that ALK fuses with is called EML4. Depending on exactly where ALK is fused with the gene, there are different ...

developed a new screening method. At CREST in 2007, Professor Mano discovered the EML4-ALK fusion gene; at Research Acceleration in 2012, he discovered the RET and ROSI fusion genes, which are all ...

In 2014 we described a simple strategy to engineer an oncogenic chromosomal inversion leading to the formation of an Eml4-Alk gene fusion in the lungs of adult wild type mice via intra-tracheal ...

The fusion file is a list of coordinated target genes together with their exons. A sample is: >EML4_ENST00000318522.5,chr2:42396490-42559688 1,42396490,42396776 2,42472645,42472827 3,42483641,42483770 ...