For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

This enzyme efficiently promotes a wide variety of S N Ar processes and can generate target products in a single mirror-image form, which is crucial for applications in the pharmaceutical sector.

causing a change in the enzyme's shape and reducing its activity regardless of substrate concentration. Feedback inhibition is a regulatory mechanism where the end product of a biochemical pathway ...

By measuring the different products generated by each mutation ... To test the effects of FAD mutations on the stability of ...

This Research Topic is still accepting articles. Identifying enzyme inhibitors has always played a crucial role within the realm of natural product research and ethnopharmacology, serving as a key ...

Optically pure alcohols are prevalent motifs in natural products and pharmaceuticals ... including a narrow substrate scope on the simple cyclic alkenes, low-to-moderate enantioselectivities ...

Their high-resolution structural studies, combined with computational analysis and site-directed mutagenesis, provide insight into how substrate specificity is achieved at the molecular level.The ...

The diagram below shows how an enzyme catalyses the breakdown of one substrate into two products.

Stratingh Institute for Chemistry, University of Groningen, 9747AG Groningen, The Netherlands ...