In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate ...

Excessive cell death has been associated with chronic inflammation as seen in patients with Crohn's disease and ulcerative colitis. While until recently apoptosis was discussed as being essential for ...

The bioenergetic requirements of muscle stem cells (satellite cells) during homeostasis and regeneration remain ill-defined. Here, genetics combined with multi-omics analyses reveal an essential role ...