14 These TACs consisted of an interleukin (IL)13/Th2-high predominantly eosinophilic cluster (TAC1) and two Th2-low gene expression clusters characterised by neutrophilic inflammation and inflammasome ...

Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

This complex process, known as gene expression, determines which proteins we make and whether we make them in the correct amounts, crucial work given that proteins play a role in virtually every a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ferroptosis, an iron-dependent form of ...

1. 澳大利亚纽卡斯尔大学的研究发现，抑制线粒体氧化磷酸化(oxphos)能抑制糖酵解功能健全的结直肠癌(crc)细胞的增殖和致瘤性。 2. 研究结果显示 ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

ImmunoMet continues to investigate additional indications using a precision medicine-guided approach where emerging data implicate OxPhos inhibition will demonstrate anti-tumor activity. Lixumistat is ...

This epigenetic modification has the potential to alter gene expression patterns, thereby impacting physiological and pathological ... This modification leads to the inactivation of these enzymes, ...

The first human trial of insulin-producing cells that have been gene-edited to evade immune attack is a success so far. The cells have survived and produced insulin for a month after being ...