在前列腺癌的研究领域，美国杜克大学医学院杜克癌症研究所前列腺与泌尿系统癌症中心的 Muthana Al Abo 等研究人员取得了一项重要进展。他们的研究成果《Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence》发表于 ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

Working at the interface of RNA splicing and breast cancer biology, our current focus is on regulation of breast cancer metastasis driven by alternative splicing. We use molecular biology, genomics, ...

Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing. This breakthrough ...

Utilizing invaluable tissue samples from global brain banks, the study sheds light on a process essential for accurate RNA splicing -- a cornerstone of proper gene expression. The researchers ...

Utilizing invaluable tissue samples from global brain banks, the study sheds light on a process essential for accurate RNA splicing—a cornerstone of proper gene expression. The researchers ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...