Plasmodium falciparum ATP4 (PfATP4) is a Na + efflux pump and represents an important target for antimalarial drugs with nanomolar potency. However, the structure of PfATP4 is unknown, prompting the development of new methodologies to ...Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type ATPase (PfATP4).

2024年12月17日 · Browse the most-recent publications from PNAS, publishing daily across the physical, social, and biological sciences.

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Gene Set Enrichment Analysis (GSEA) is a powerful method for interpreting gene expression data by focusing on groups of genes with common functions.

PNAS | November 2024 | vol. 121 | i–xxx Submit to the Proceedings of the National Academy of Sciences (PNAS) and have your research discovered by millions of researchers in the biological, physical, and social sciences. About PNAS PNAS has been at the forefront of scientific research for over a century.

2025年1月13日 · Soil microbial communities are often exposed to pulse events (1, 2)—discrete, sudden changes in the environment ().Identifying biological traits that predict response of organisms to pulse events is a central challenge in determining how these events impact ecosystem function ().Rewetting of dry soil is a common and ecologically important pulse event where microbial traits associated with ...

2022年10月24日 · The pathophysiological mechanisms underlying the constellation of symptoms that characterize COVID-19 are only incompletely understood. In an effort to fill these gaps, a “nicotinic hypothesis,” which posits that nicotinic acetylcholine receptors (AChRs) act as additional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Numerical simulation of fluids plays a crucial role in modeling physical phenomena such as weather, climate, aerodynamics, and plasma physics.

Lipid nanoparticles (LNPs) are a versatile platform for nucleic acid delivery, particularly for mRNA vaccines, but face challenges in endosomal escape.

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