Most of the studies showed improved outcome with use of ketamine in acute severe asthma unresponsive to conventional treatment. Patients who received ketamine improved clinically, had lower oxygen requirements, and obviated the need for invasive ventilation.

2023年4月12日 · basics: how to provide dissociative-dose ketamine sedation in asthma: (1) Ketamine dosing: Load with 1-2 mg/kg bolus. Infusion at 1-4 mg/kg/hour. (2) Other sedatives and analgesics can generally be stopped. (However, a propofol infusion may still be needed if there is problematic tachypnea that is causing gas trapping.)

These properties suggest intravenous (IV) ketamine has a role in the management of status asthmaticus, particularly in refractory cases, but data remains limited. CASE PRESENTATION: Six patients (age 56 ±16 years, 33.3% female) receiving IV ketamine for status asthmaticus at a single center were identified through retrospective chart review.

Efficient treatment of asthma can play an important role in controlling asthma attacks, rapid recovery and decrease of patient mortality. Therefore, in the present study the therapeutic effect of low-dose ketamine is evaluated in patients with acute asthma attack.

The use of ketamine in severe asthma has been advocated for its sympathetic stimulation and the consequent relaxation of smooth muscles and bronchodilation . Therefore, ketamine may improve lung compliance and reduce airways resistances when administered as a continuous infusion.

It seems that administration of 0.4 - 0.5 mg/kg doses of intravenous ketamine followed by infusion of the same dose during 30 minutes can be effective for rapid recovery of PEFR in patients with mild to moderate asthma.

2024年6月16日 · Ketamine's anti-inflammatory properties, bronchodilatory effects, and well-documented history contribute to its ability to provide a significant clinical asthma score (CAS) reduction and improvement on pulmonary readings, such as peak expiratory flow (PEF), while providing a well-researched adverse effect profile.

2021年11月30日 · In this study we aimed to compare the effects of two enhancing strategies, the nebulized ketamine and IV magnesium sulfate, in treatment of severe steroid resistant asthma. This double-blind randomized clinical trial was conducted on patients who presented to a referral clinic in Alborz, Iran.

2013年10月25日 · The use of ketamine as a sedative for intubation and mechanical ventilation of children with severe asthma attacks has been well described. 5 Ketamine maintains cardiac performance and airway reflexes while providing analgesia, amnesia, and decreased airway resistance. 6 According to these physiologic benefits, one would expect ketamine to be ...

In various studies, ketamine has been found to be a potential bronchodilator in severe asthma. However, a large prospective clinical trial is warranted before laying down any definitive recommendations on its use in status asthmaticus.