The landscape for rare diseases in 2024
By definition, rare diseases affect a small number of individuals (fewer than 1 in 2000 people in any WHO region); yet, with more than 7000 types of rare disease in existence, the burden worldwide is not insignificant. To date, approximately 300 million people live with rare diseases. Such individuals are often a neglected and marginalised group, especially those in low-income …
Latest advances in treatment for non-small cell lung cancer - The …
2024年3月4日 · Lung cancer is the most commonly occurring cancer globally, and the leading cause of cancer death worldwide. 85% of all lung cancer cases are categorised as non-small cell lung cancer (NSCLC).
WHO 2024 hepatitis B guidelines: an opportunity to transform care
2024年4月10日 · Chronic hepatitis B virus (HBV) infection is a major public health problem and cause of chronic liver disease and led to an estimated 1·1 million deaths in 2022, mainly due to cirrhosis and hepatocellular carcinoma.1 In 2022, WHO estimated that 254 million people were living with chronic hepatitis B, of whom 65% were in the African and Western Pacific regions.1 …
Global burden of bacterial antimicrobial resistance in 2019: a ...
2022年2月12日 · To our knowledge, this study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data. AMR is a leading cause of death around the world, with the highest burdens in low-resource settings. Understanding the burden of AMR and the leading pathogen–drug combinations contributing …
Long COVID: a clinical update - The Lancet
2024年7月31日 · Post-COVID-19 condition (also known as long COVID) is generally defined as symptoms persisting for 3 months or more after acute COVID-19. Long COVID can affect multiple organ systems and lead to severe and protracted impairment of function as a result of organ damage. The burden of this disease, both on the individual and on health systems and …
Antiviral effect of high-dose ivermectin in adults with COVID-19: A ...
2021年6月17日 · Our study contributes evidence of the antiviral activity of ivermectin against SARS-CoV-2 in patients with COVID-19 through a randomized, controlled, outcome-assessor blinded clinical trial with innovative analyses that include the use of quantitative viral load determinations and measurement of ivermectin plasma levels, which allow an in-depth …
Clinical advances and ongoing trials of mRNA vaccines for cancer ...
Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 pandemic. Therapeutic cancer vaccines based on mRNA are well tolerated, and the inherent advantage in ease of production, which rivals the best available conventional vaccine manufacture methods, …
Global burden of 369 diseases and injuries in 204 countries and ...
As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy …
Influenza - The Lancet
Annual seasonal influenza epidemics of variable severity caused by influenza A and B virus infections result in substantial disease burden worldwide. Seasonal influenza virus circulation declined markedly in 2020–21 after SARS-CoV-2 emerged but increased in 2021–22. Most people with influenza have abrupt onset of respiratory symptoms and myalgia with or without …
Treatment outcomes for depression: challenges and opportunities
2020年2月17日 · Depressive disorders are common, costly, have a strong effect on quality of life, and are associated with considerable morbidity and mortality. Effective treatments are available: antidepressant medication and talking therapies are included in most guidelines as first-line treatments. These treatments have changed the lives of countless patients worldwide for the …